ICMR-National Institute of Cholera and Enteric Diseases
आई सी एम आर - राष्ट्रीय कॉलरा और आंत्र रोग संस्थान
Department of Health Research, Ministry of Health and Family Welfare, Government of India
स्वास्थ्य अनुसंधान विभाग, स्वास्थ्य और परिवार कल्याण मंत्रालय, भारत सरकार
NICED : Scientists
Dr. Moumita Bhaumik (Ghosh)
| Name | Dr. Moumita Bhaumik (Ghosh) |
|---|---|
| Designation | Scientist C |
| Date of joining ICMR | 06 November 2017 |
| Date of joining present post | 06 November 2017 |
| Discipline | Immunology |
| Division | |
| Specialization | |
| Email : | drmoumitabhaumik@gmail.com |
| Academic Qualification | |
| Graduation | Zoology, University of Calcutta |
| Post Graduation | Biophysics and Molecular biology. University of Calcutta |
| Doctoral | Biophysics and Molecular biology, CSIR-IICB, Kolkata |
Profile
Research Experience
My doctoral research experience revolved around the
pathogenesis of the Leishmania infection.
Leishmania, a protozoan parasite causing the disease
Kala-azar exhibit a pronounced tropism for macrophages.
Once, the parasite is well established, it causes
aberrant changes in macrophage property and function. My
study was designed to understand the 'complex rules' by
which Leishmania parasites modulate the
biological functions of the macrophage affecting the
antileishmanial immune repertoire. All the studies were
restricted on three aspects of cell biology of
Leishmania infected macrophage - the macrophage
membrane function, effective immune stimulation by
antileishmanial drugs and antigen processing and
presentation of exogenous antigen. Thus, it was shown
how Leishmania parasites modulate the macrophage
function which may have significant impact on the
immunopathology of Leishmaniasis.
Research Interest
I thrust my interest on commensal bacteria which constitutes an ecosystem inside our gut, known as "microbiome". It has a protective, metabolic and trophic functions thus regulating various physiological system of our body. For which, the body requires keyinduction and maintenance signals from microbiome, many of them are yet to be discovered. I would pursue my studies on the following aspects of gut microbiotaand host interactionto find out the key factor. First, the impact of microbiome on immune system of the host. Second, the mechanism by which it orchestrates the physiology of the host. Third, the environmental factorsand antibiotics on perturbing gut microbiome, affecting host physiology.
Awards
- A. K. Memorial medal for first class first in B.Sc(Zoology) from University of Calcutta (2004)
Publications
2014
-
Ghosh M, Roy K, Das Mukherjee D, Chakrabarti G, Roy
Choudhury K, Roy S. Leishmania donovani infection
enhances lateral mobility of macrophage membrane protein which
is reversed by liposomal cholesterol. PLoS Negl Trop Dis. 2014
Dec 4;8(12):e3367. .
Pubmed
-
Roy K, Naskar K, Ghosh M, Roy S. Class II MHC/peptide
interaction in Leishmania donovani infection:
implications in vaccine design. J Immunol. 2014 Jun
15;192(12):5873-80
Pubmed
2013
-
Ghosh M, Roy K, Roy S. Immunomodulatory effects of
antileishmanial drugs. J Antimicrob Chemother. 2013
Dec;68(12):2834-8
Pubmed
-
Roy K, Ghosh M, Pal TK, Chakrabarti S, Roy S.
Cholesterol lowering drug may influence cellular immune response
by altering MHC II function. J Lipid Res. 2013
Nov;54(11):3106-15.
Pubmed
-
Ghosh M, Solanki AK, Roy K, Dhoke RR, Ashish, Roy S.
Carrier protein influences immunodominance of a known epitope:
implication in peptide vaccine design. Vaccine. 2013 Sep
23;31(41):4682-8.
Pubmed
2012
-
Datta S, Manna M, Khanra S, Ghosh M, Bhar R,
Chakraborty A, Roy S. Therapeutic immunization with
radio-attenuated Leishmania parasites through i.m. route
revealed protection against the experimental murine visceral
leishmaniasis. Parasitol Res. 2012 Jul;111(1):361-9.
Pubmed
2011
-
Bhattacharya P, Gupta G, Majumder S, Adhikari A, Banerjee S,
Halder K, Majumdar SB, Ghosh M, Chaudhuri S, Roy S,
Majumdar S. Arabinosylated lipoarabinomannan skews Th2 phenotype
towards Th1 during Leishmania infection by chromatin
modification: involvement of MAPK signaling. PLoS One.
2011;6(9):e24141.
Pubmed
2009
-
8. Banerjee S, Ghosh J, Sen S, Guha R, Dhar R, Ghosh M, Datta S,
Raychaudhury B, Naskar K, Haldar AK, Lal CS, Pandey K, Das VN,
Das P, Roy S. Designing therapies against experimental visceral
leishmaniasis by modulating the membrane fluidity of
antigen-presenting cells. Infect Immun. 2009 Jun;77(6):2330-42.
Pubmed